Final answer:
The item in The Binding of Isaac that gives bombs a homing effect and grants +5 Bombs is Bobby Bomb (Option A).
Step-by-step explanation:
In the game The Binding of Isaac, the item that provides Isaac's bombs with a homing effect upon placement on the floor and grants an additional +5 Bombs is known as A) Bobby Bomb. Bobby Bomb makes each bomb you place actively seek out nearby enemies before detonation, adding a strategic element to your bomb placement. Furthermore, the addition of +5 Bombs upon pickup allows for more frequent use of bombs in gameplay, aiding in both combat and the exploration of secret rooms.