Final answer:
In Immune-Mediated Hemolytic Anemia (IMHA), spherocytes are the common cellular morphology change, characterized by spherical red blood cells due to the immune system targeting and destroying the RBC membrane.
Step-by-step explanation:
The cellular morphology change often associated with Immune-Mediated Hemolytic Anemia (IMHA) is the presence of spherocytes. Spherocytes are red blood cells (RBCs) that appear more sphere-like rather than the classic biconcave disk shape typical of normal erythrocytes. In IMHA, the body's immune system mistakenly targets its own RBCs, leading to the destruction of the red blood cell membrane, giving them a spherical shape. This is different from sickle cell anemia, where the abnormality in hemoglobin causes the cells to become crescent or sickle-shaped under low oxygen conditions. A blood smear taken from a patient with IMHA will show these spherocytes when examined under microscopy.