Final answer:
The Intracellular Fluid (ICF) compartment, comprising about 60 percent of the body's water, is the largest and makes up the majority of total body water.
Step-by-step explanation:
The compartment of water that makes up the majority of total body water is the Intracellular Fluid (ICF). The ICF is the fluid within the cells and is a significant constituent of the cytosol or cytoplasm. It accounts for about 60 percent of the total water in the human body. In an average-sized adult male, the ICF represents about 25 liters of fluid. This is more than any other compartment, including extracellular fluid which is only about 20 percent of the body weight, divided into components such as interstitial fluid and blood plasma.