Question

Why is EDTA preferred over heparin in most species for blood collection?

A) EDTA provides better clotting activation.
B) Heparin interferes with red blood cell counts.
C) EDTA is more effective in preserving cell morphology.
D) Heparin prevents platelet aggregation.

Answer 1

EDTA is preferred over heparin in most species for blood collection because it is more effective at preserving cell morphology without interfering with coagulation or platelet aggregation.

Step-by-step explanation:

The student has asked why EDTA is preferred over heparin for blood collection in most species. The correct answer is C) EDTA is more effective in preserving cell morphology. Unlike heparin, EDTA works by binding calcium ions, which are necessary for the coagulation process. By removing calcium, EDTA effectively prevents blood clotting, which preserves the morphology of cells in the collected blood sample. This is crucial for accurate hematological tests where cell size, shape, and number are important. Heparin, on the other hand, works by activating antithrombin III, which in turn inhibits thrombin and other proteins involved in the coagulation cascade.

Therefore, EDTA is generally the preferred anticoagulant for routine hematology tests because it ensures a clear and undistorted view of cells, which is essential for differential cell counts and morphological examinations.