Final answer:
Leonardo da Vinci is known to have been involved in music, but historical records do not explicitly detail which instruments he played. The most likely instruments he might have played during the Renaissance are the harp and lyre, as the piano and violin-like instruments were not prevalent during his lifetime.
Step-by-step explanation:
Leonardo da Vinci was a true polymath of the Renaissance, known for his contributions across multiple fields including painting, engineering, science, and music. As part of his wide array of talents, he also ventured into composing music and played musical instruments. Though there are various accounts of what instruments Leonardo may have played, the definitive list is not well-documented. Based on the instruments popular during the Renaissance period and the musical practices of the time, it's possible he might have played instruments such as the lyre or the lute. However, in terms of the options provided: a) Violin and flute, b) Harp and lyre, c) Piano and organ, or d) Viola and drums, given that the piano was not invented until after his death, and both the violin and viola came into prominence later as well, the most historically accurate guess from these options would be (b) Harp and lyre, which were prevalent during da Vinci's lifetime. It is important to note that specific historical records of da Vinci's musical capabilities, including what instruments Da Vinci played, are not explicit in the historical texts available to us.