Question

Statement A: A Vd of ≥ 0.6L/kg is required for drugs that interact with nuclear receptors Statement B: B Very lipophilic drugs are not easily excreted via the kidneys.

A) Both A and B are true statements, and B is the correct explanation of A.
B) Both A and B are true statements, but B is not the correct explanation of A.
C) Statement A is true, and Statement B is false.
D) Statement A is false, and Statement B is true.

Answer 1

Statement A is true, and Statement B is false.

Step-by-step explanation:

Statement A: A Vd of ≥ 0.6L/kg is required for drugs that interact with nuclear receptors
Statement B: Very lipophilic drugs are not easily excreted via the kidneys.
The correct answer is C) Statement A is true, and Statement B is false.
A large volume of distribution (Vd) of ≥0.6L/kg indicates that a drug is extensively distributed throughout the body and is not confined to the plasma compartment. This is important for drugs that interact with nuclear receptors, as they need to be available in various tissues.Lipophilic drugs, on the other hand, tend to be easily absorbed into fatty tissues and are not easily excreted via the kidneys. However, lipophilicity is not directly related to excretion via the kidneys. There are other factors, such as molecular size and charge, that determine renal elimination.