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What happens if a late progress zone is transplanted onto an early wing bud?

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Final answer:

Transplanting a late progress zone onto an early wing bud disrupts limb development, potentially causing malformed development due to the imposition of mature developmental information on younger tissue.

Step-by-step explanation:

When a late progress zone is transplanted onto an early wing bud, it can disrupt the normal development and patterning of the limb. In developmental biology, the concept of the progress zone is important for understanding how limbs develop along a proximal-to-distal axis. Cells in the progress zone proliferate rapidly, and as they move away from the apical ectodermal ridge, their rate of cell division decreases and they begin to differentiate. Transplanting a late progress zone, which contains cells that have already begun to differentiate, onto an early wing bud can impose the more mature developmental information upon the younger tissue, potentially altering the developmental fate of the younger cells and leading to malformed limb development.

This concept can be compared to the seminal experiments by Spemann and Mangold, where cells transplanted from the dorsal part of an embryo to the ventral side led to the formation of additional notochords. Similarly, transplanting cells with one set of developmental instructions to a different context can lead to irregular development. The outcome of such a transplantation would be highly variable and would depend on the specifics of the progress zone and wing bud involved, including the stage of development and the type of signals that the transplanted cells might carry or induce.

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