Question

Which statement is true about the ob/ob mouse model?

A) The ob/ob mouse has a mutation that results in a truncated (inactive) form of leptin

B) Increased levels of leptin in the ob/ob mouse are responsible for the obese phenotype observed in these mice

C) The ob/ob mouse is resistant to the actions of the adipokine, leptin

Answer 1

The true statement about the ob/ob mouse model is that it has a mutation which causes an inactive form of leptin, leading to obesity.

Step-by-step explanation:

The statement that is true about the ob/ob mouse model is A) The ob/ob mouse has a mutation that results in a truncated (inactive) form of leptin. The ob/ob mouse model is crucial in studying the pathophysiology of obesity, particularly the role of leptin resistance. Leptin is a hormone produced by adipose tissues that is essential for regulating hunger and energy balance. When functional, leptin signals to the brain to decrease food intake and increase energy expenditure. However, in the ob/ob mice, due to a genetic mutation, they produce an inactive form of leptin, which leads to unregulated appetite and results in obesity.