Final answer:
The signs of methamphetamine intoxication include an elevated mood and increased energy levels, while withdrawal is characterized by fatigue and disturbed sleep patterns. High doses can lead to serious psychological effects, and withdrawal can cause a prolonged post-withdrawal syndrome with a combination of physical and psychological symptoms.
Step-by-step explanation:
The common signs of methamphetamine intoxication are an elevated mood and increased energy levels, which manifest as heightened alertness, concentration, and energy even in individuals who are fatigued. On the other hand, methamphetamine withdrawal is characterized by fatigue and disturbed sleep patterns, alongside other possible symptoms such as intense cravings, depression, and anxiety.
Methamphetamine, especially at higher doses, can lead to severe psychological effects such as psychosis, paranoia, and hallucinations. Physical effects at high doses can include rhabdomyolysis and cerebral hemorrhage, while long-term use is associated with significant brain damage and changes in brain structure and function, including reductions in gray matter volume.
Withdrawal from methamphetamine can produce a post-withdrawal syndrome that persists for months, featuring a combination of physical and psychological symptoms, including mood disturbances and cognitive issues arising from neurotransmitter depletion.