Final answer:
In a cardiovascular examination, inspect the legs for peripheral edema, which is fluid buildup due to potential heart or venous issues, not related to cranial nerve abnormalities, retinal detachment, or respiratory distress.
Step-by-step explanation:
During a cardiovascular examination, you should inspect the legs for Option 2: Peripheral edema. Peripheral edema is the accumulation of fluid in the tissues, most often observed in the lower limbs due to gravity's influence on blood flow. The presence of edema may indicate cardiovascular problems such as heart failure or venous insufficiency. It is important to note that this condition is distinct from other options listed, such as cranial nerve abnormalities, retinal detachment, and respiratory distress, which are not typically associated with an examination of the legs in the context of cardiovascular health.