Final answer:
Three topological characteristics of a multi-pass TM membrane that can be predicted from its sequence are the number of transmembrane helices, amino acid composition, and orientations of the helices.
Step-by-step explanation:
Three topological characteristics of a multi-pass TM (transmembrane) membrane that can be predicted from its sequence include:
- Number of transmembrane helices: The sequence can provide information about the number of helices that span the membrane. This can be determined by analyzing the presence of hydrophobic regions in the sequence, which are indicative of transmembrane helices.
- Amino acid composition: The sequence can reveal the amino acid residues present in the membrane-spanning regions. This information is important in understanding the structure and function of the membrane protein.
- Orientations of the helices: The sequence can provide clues about the arrangement of the transmembrane helices in the membrane. This can be inferred by analyzing the patterns of hydrophobic and hydrophilic residues in the sequence.