Final answer:
HSP-70 bound to ATP is in an open conformation, while bound to ADP, it is in a closed conformation.
Step-by-step explanation:
The conformation of HSP-70 depends on whether it is bound to ATP or ADP. When HSP-70 is bound to ATP, it is in an open conformation that allows for substrate binding and release. When ATP is hydrolyzed to ADP, HSP-70 undergoes a conformational change and adopts a closed conformation that tightly binds ADP and the remaining phosphate group. The tight-state conformation promotes the release of the substrate and the formation of ATP.