Question

Describe the HSP-90 binding cycle?

Answer 1

In eukaryotes, Hsp90 proteins are essential. They participate in the remodeling and activation of hundreds of diverse client proteins, including transcription factors, regulatory kinases, signaling proteins, and numerous other proteins that lack common structural or functional features.

Answer 2

The HSP-90 binding cycle involves the interaction of HSP-90 with various client proteins in a series of steps including recruitment, conformational changes, and dissociation.

Step-by-step explanation:

The HSP-90 binding cycle involves the interaction of HSP-90 (heat shock protein 90) with various client proteins.

HSP-90 is a molecular chaperone that helps in the proper folding and stabilization of client proteins.

The binding cycle consists of several steps:

HSP-90 is then ready to initiate another binding cycle with a new client protein.