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A point mutation in a protein-coding gene results in the specification of the same amino acid. What is the term used for this type of mutation?

a) Missense mutation
b) Silent mutation
c) Nonsense mutation
d) Frameshift mutation

1 Answer

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Final answer:

The correct term for a point mutation that specifies the same amino acid is a silent mutation. This type of mutation does not alter the amino acid sequence of the protein, and it occurs because of the redundancy in the genetic code.

Step-by-step explanation:

A point mutation in a protein-coding gene that results in the specification of the same amino acid is termed a silent mutation. This occurs because the genetic code has a redundancy, which allows multiple codons to code for the same amino acid. Hence, even with a base pair change, the resulting amino acid sequence of the protein remains unchanged. An example of a silent mutation would be a change from the codon CCA to CCU, both of which code for the amino acid proline.

On the other hand, a missense mutation results in the codon coding for a different amino acid, which may have varying effects on the protein function depending on the nature of the substituted amino acid. The sickle cell disease is an example of a disease caused by a missense mutation. A nonsense mutation is a point mutation that results in a codon becoming a stop codon, leading to premature termination of protein synthesis. A deletion leading to the loss of a single nucleotide can result in a frameshift mutation, which alters the entire downstream amino acid sequence.

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