Final answer:
Neurons principally communicate via chemical and electrical signals, with chemicals like neurotransmitters playing a key role in chemical synapses.
Step-by-step explanation:
Neurons communicate with one another primarily through chemical signals and electrical signals. During a chemical synapse, neurotransmitters are released from the axon terminals of the presynaptic neuron into the synaptic cleft. These chemical signals are then picked up by the receptors on the dendrites or cell body of the postsynaptic neuron, leading to the transmission of the signal. On the other hand, electrical synapses involve direct electrical communication through gap junctions between neurons, where the electrical current flows directly from one neuron to another.