Final answer:
After 16 hours, which equals two half-lives, the concentration of the drug in the bloodstream decreases by a factor of 1/4.
Step-by-step explanation:
The half-life of a substance is the time it takes for its concentration to reduce to half its initial value. In the context of the question, the drug in question has a half-life of 8 hours, meaning after 8 hours, its concentration decreases to one-half of the original amount. After 16 hours, which is two half-lives, the concentration would reduce by a factor of two twice, or by a factor of four (22).
Using the formula for the concentration after n half-lives:
(1/2)n × initial concentration
For two half-lives, this becomes:
(1/2)2 = 1/4
Thus, after 16 hours, the concentration of the drug in the bloodstream decreases by a factor of 1/4.