Final answer:
Genetic drift has the most significant impact on small populations because individual events can have a larger effect on the population's gene pool, changing allele frequencies much more than in larger populations where such events have a diluted impact.
Step-by-step explanation:
Genetic drift is most powerful in small populations. Small populations are susceptible to the forces of genetic drift because they have a smaller gene pool compared to large populations. In such populations, chance events can significantly alter allele frequencies. For example, if one individual in a population of ten dies before reproducing, 10% of the gene pool is lost. In contrast, in a population of 100, the loss of one individual impacts only 1% of the gene pool. This difference in impact is why genetic drift has more profound effects in smaller populations. Events like natural disasters can exacerbate this by reducing genetic variation if they impact specific alleles more than others, as seen with the example of white rabbits being killed in a storm.