Final answer:
To define a variable x with the value of 10 in Python, use the assignment operator (=) and assign 10 to x.
Step-by-step explanation:
In Python, the assignment operator (=) is employed to define a variable and assign a specific value. For instance, to create a variable named "x" with a value of 10, the code would be written as follows:
```python
x = 10
```
Upon execution, the variable "x" is instantiated with the assigned value of 10. This fundamental syntax encapsulates Python's dynamic typing, allowing for flexible variable declarations. Variables serve as placeholders for data, facilitating manipulation and reference within the program. Python's simplicity and readability are evident in this concise statement, highlighting the language's emphasis on clarity and efficiency. As a dynamically-typed language, Python enables developers to effortlessly create and modify variables, fostering a streamlined coding experience.