Final answer:
The epidermal layer responsible for the production of glycolipids that contribute to waterproofing the skin is the stratum granulosum. This layer's secretion of lipids is crucial for forming a barrier that minimizes water loss from the body.
Step-by-step explanation:
The layer of the epidermis responsible for producing glycolipids to aid in "waterproofing" is the stratum granulosum. The epidermis is the outermost layer of the skin, which serves as a barrier to water and invasion by pathogens. Within this outer layer, the epidermis consists of multiple strata (layers), among which the keratinocytes in the stratum spinosum begin the synthesis of keratin and release a water-repelling glycolipid.
However, it is the cells of the stratum granulosum that are known for their role in enhancing the waterproof capabilities of the skin. The layers of keratinocytes that make up the stratum granulosum secrete lipids that aid in the formation of a waterproof barrier, effectively preventing excess water loss from the body.