Final answer:
Substance abuse costs U.S. companies nearly $100 billion annually, a substantial economic burden which reflects productivity losses and healthcare costs.
Step-by-step explanation:
Given the information from various sources, the correct answer to how much money substance abuse costs U.S. companies annually is nearly $100 billion. This is a significant economic impact, reflecting costs associated with loss of productivity, health care expenses, and other related issues. This figure is on the low end when compared to the compliance costs for environmental laws which have been estimated at more than $200 billion. It indicates the magnitude of the challenge that substance abuse presents to both businesses and society at large.