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______ is a method for combining two or more ingredients of differing strengths into an ointment or cream base.

a. sifting
b. trituration
c. spatulation
d. geometric dilution

User Ichbinjoe
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Final answer:

Geometric dilution is a method employed in pharmaceutical compounding to evenly mix ingredients of different concentrations into a homogeneous ointment or cream. It ensures consistent dosages and is also applied in preparing diluted solutions from concentrated stock solutions, critical in laboratory settings or with products that require dilution like pesticides. Creams and ointments are typical formulations where geometric dilution is essential.

Step-by-step explanation:

Geometric dilution is a method used in pharmaceutical compounding to combine two or more ingredients of differing concentrations into a homogenous ointment or cream base. This technique ensures that the stronger ingredient is slowly and evenly dispersed within the base, preventing areas of high concentration, which is critical for providing consistent dosages and ensuring the safety and efficacy of the medication.

The principle of geometric dilution can be applied to various areas, including preparation of solutions, such as diluting concentrated stock solutions to achieve desired concentrations for use. This is frequently done with laboratory reagents and commercial products like pesticides which require dilution before application. It's essential in creating solutions from concentrated aqueous solutions, such as strong acids, and when addressing common dilution problems that involve calculating the necessary amount of a concentrated stock solution needed to create a solution with a lesser concentration.

Creams and ointments are examples of pharmaceutical formulations that may utilize geometric dilution. Creams are divided into oil-in-water and water-in-oil emulsions, with their usage depending on the properties of the active ingredient and desired cosmetic properties. Ointments, being semi-solid dosage forms, are primarily used for topical application, and the active medication is evenly distributed through geometric dilution.

User John Gorenfeld
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