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As unwinding of the helix occurs during DNA replication, tension is created ahead of the replication fork. Describe the nature of this tension and state the manner in which this tension is resolved (what enzyme)?

A) Positive supercoiling; resolved by topoisomerase
B) Negative supercoiling; resolved by helicase
C) Negative supercoiling; resolved by topoisomerase
D) Positive supercoiling; resolved by ligase

1 Answer

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Final answer:

The tension created by unwinding the DNA helix during replication is positive supercoiling, which is resolved by the enzyme topoisomerase by cutting and rejoining the DNA strands.

Step-by-step explanation:

During DNA replication, the unwinding of the helix causes tension that leads to positive supercoiling ahead of the replication fork. This tension is resolved by the enzyme topoisomerase. The topoisomerase enzyme works by cutting and then rejoining the DNA strands, allowing the helix to relax and continue the replication process without damaging the DNA molecule.

The tension created ahead of the replication fork during DNA replication is due to negative supercoiling. This occurs as the DNA strands unwind and separate. The enzyme responsible for resolving this tension is topoisomerase. Topoisomerase breaks and reforms the DNA's phosphate backbone ahead of the replication fork, relieving the pressure caused by the supercoiling.

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