Final answer:
The statement is true; primary active transporters use ATP to move substances against an electrochemical gradient, creating a difference in charge across the cell membrane.
Step-by-step explanation:
The statement that primary active transporters are similar to carriers, with the exception that they are able to use energy to move ions against their electrochemical gradient, is true. Primary active transport directly uses energy, usually in the form of ATP, to move substances such as ions across a cell membrane, often against a concentration gradient. This creates a difference in charge, or an electrochemical gradient, across the membrane.
The proteins involved in this process, which can transport small, uncharged organic molecules like glucose, are known as pumps. Specifically, the sodium-potassium pump is a well-known example of a primary active transporter that exchanges sodium for potassium ions across the plasma membrane using ATP as an energy source.