Question

In humans there is a genetic disorder that results from a dominant mutation present in a gene located in the pseudoautosomal region of the Y chromosome and on the X chromosome.Which of the following statements is CORRECT?

a) Affected individuals inherit the mutation only from their fathers.
b) Affected individuals can inherit the mutation from either parent.
c) Affected individuals inherit the mutation only from their mothers.
d) The mutation occurs exclusively on the Y chromosome.

Answer 1

Affected individuals can inherit a genetic disorder caused by a dominant mutation present in the pseudoautosomal region from either parent because this region is found on both the X and Y chromosomes.

The correct statement is option b) Affected individuals can inherit the mutation from either parent.

Step-by-step explanation:

This is because the pseudoautosomal regions are the areas of the X and Y chromosomes that are identical and can undergo recombination.

Thus, the mutation can be transmitted by either an affected mother, through her X chromosome, or an affected father, through either his X or transmissible Y chromosome. It is important to note that while the Y chromosome is only inherited from the father, the pseudoautosomal regions are not exclusive to it and can also be part of the X chromosome inherited from the mother.

The correct answer to the question regarding the inheritance of a genetic disorder caused by a dominant mutation in the pseudoautosomal region of the Y chromosome and on the X chromosome is: b) Affected individuals can inherit the mutation from either parent.