Question

Match the reactant in gluconeogenesis on the left with the appropriate enzyme on the right.

A) hexokinase
B) phosphoenolpyruvate carboxykinase
C) oxaloacetate kinase
D) aldolase
E) pyruvate carboxylase
F) pyruvate kinase
G) phosphoglyceromutase
H) fructose-1,6-bisphosphatase
I) glucose-6-phosphatase

7) pyruvate
8) oxaloacetate
9) fructose-1,6-bisphosphate
10) glucose-6-phosphate
11) 2-phosphoglycerate

Answer 1

In gluconeogenesis, pyruvate is converted into oxaloacetate by pyruvate carboxylase, oxaloacetate into phosphoenolpyruvate by phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphate into fructose-6-phosphate by fructose-1,6-bisphosphatase, and glucose-6-phosphate into glucose by glucose-6-phosphatase.

Step-by-step explanation:

The question concerns matching reactants in gluconeogenesis with the appropriate enzymes. In gluconeogenesis, the process begins with pyruvate (7) which is first converted into oxaloacetate (8) using the enzyme pyruvate carboxylase (E). Oxaloacetate is then used as a substrate for the enzyme phosphoenolpyruvate carboxykinase (B) to form phosphoenolpyruvate.

Fructose-1,6-bisphosphate (9) is converted into fructose-6-phosphate by the enzyme fructose-1,6-bisphosphatase (H). Glucose-6-phosphate (10) is ultimately dephosphorylated by the enzyme glucose-6-phosphatase (I) to produce glucose. 2-Phosphoglycerate (11), on the other hand, is interconverted with 3-phosphoglycerate by the enzyme phosphoglyceromutase (G).