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Consider the hypothesis that disease causing agents naturally evolve into more benign forms as the immune system of their hosts evolve more efficient responses to them. Is the evidence we have reviewed on the evolution of HIV within and among hosts consistent with this hypothesis? Why or why not?

User Siddharood
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Final answer:

The evidence on the evolution of HIV indicates that the virus rapidly adapts to evade immune responses and drug treatments, suggesting that it is not evolving into a more benign form but rather increasing its ability to persist and evade medical interventions.

Step-by-step explanation:

The evolution of HIV does not consistently support the hypothesis that disease-causing agents evolve into more benign forms. Although treatments for HIV have advanced, the virus's high mutation rate enables it to adapt quickly to selective pressures, such as the immune response and antiretroviral drugs. For example, because HIV mutates rapidly, antigenic variation occurs and this significantly hinders the development of an effective vaccine. Additionally, when faced with drug treatments, non-resistant viruses are quickly outcompeted by drug-resistant strains, leading to a population of HIV that is even harder to treat.

The ongoing changes in HIV indicate that it is not evolving to become less virulent but is instead evolving to survive and replicate despite the immune response and current medical interventions. Consequently, the adaptive immune evasion of HIV contrasts with the idea that pathogens become more benign over time as hosts develop more efficient immune responses.

User Paradius
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