Final answer:
The sign of inflammation caused by exudate in tissue spaces is edema (swelling), one of the four cardinal signs of inflammation documented since ancient times.
Step-by-step explanation:
The specific sign of inflammation that is the result of exudate in the tissue spaces is edema (swelling). When inflammation occurs, various processes lead to the accumulation of fluid, or exudate, which can cause tissue to swell. The four cardinal signs of inflammation are redness, swelling, pain, and heat, as first recorded by Cornelius Celsus in the Roman Empire. Occasionally, a fifth sign, loss of function, may also be present. Edema is specifically caused by the increased movement of leukocytes and fluid through opened capillaries to the site of inflammation or injury. The inflammation process, which includes swelling, helps to bring phagocytic cells to the affected area to clear out debris and set the stage for repair.