Question

Mutations in the _____________gene result in frontotemporal lobar degeneration, a common cause of pre-senile dementia.

Answer 1

Mutations in the apolipoprotein E (APOE) gene result in frontotemporal lobar degeneration, a common cause of pre-senile dementia.

Step-by-step explanation:

Mutations in the apolipoprotein E (APOE) gene result in frontotemporal lobar degeneration, a common cause of pre-senile dementia. Frontotemporal lobar degeneration is a neurodegenerative disorder characterized by the progressive deterioration of the frontal and temporal lobes of the brain, leading to personality changes, language difficulties, and cognitive impairment.

One particular variant of the APOE gene, E4, increases a carrier's likelihood of developing Alzheimer's disease. However, many other genes have also been identified that may be involved in the pathology of Alzheimer's disease.