Final answer:
Abnormal presenilin is associated with certain forms of early onset Alzheimer's disease.
Step-by-step explanation:
Early onset Alzheimer's disease (AD) can be caused by mutations in certain genes, including presenilin. This rare form of AD affects a small percentage of patients and typically starts between the ages of 30 and 60, causing dementia. Another gene called apolipoprotein E (APOE) also plays a role in the more common late-onset form of AD.