Final answer:
The most appropriate treatment for the pregnant woman with current opioid use is Buprenorphine. Naloxone combined with buprenorphine is typically avoided in pregnancy, and Naltrexone is not recommended during this time.
Step-by-step explanation:
The most appropriate pharmacotherapy for a 24-year-old G1P0 woman at 14 weeks gestation seeking treatment for current opioid use is Buprenorphine. This medication is used to treat opioid dependence and is considered safe to use during pregnancy. Buprenorphine itself is a partial opioid agonist, which can reduce cravings and withdrawal symptoms without producing the same level of euphoria or risk of misuse as other opioids like heroin.
Naloxone, in combination with buprenorphine, is typically avoided in pregnancy due to the risk of precipitating withdrawal. Naltrexone, while useful for maintaining a drug-free state in addicts, is not recommended during pregnancy. Other medications such as Clonidine may alleviate some symptoms of opioid withdrawal but are not recommended as first-line treatments during pregnancy, and Olanzapine is not used for opioid dependence treatment.