Final answer:
The atypical antipsychotics most associated with metabolic syndrome effects in descending order are Clozapine, Olanzapine, Quetiapine, Risperidone, Ziprasidone, and Aripiprazole.
Step-by-step explanation:
The atypical antipsychotics most associated with weight gain, diabetes, and dyslipidemias, which are hallmarks of metabolic syndrome, in descending order are:
- Clozapine
- Olanzapine
- Quetiapine
- Risperidone
- Ziprasidone
- Aripiprazole
These medications are known to have varying levels of risk for these side effects, with clozapine and olanzapine having the highest association, and ziprasidone and aripiprazole having the lowest. It is important to monitor patients on these medications for signs of metabolic syndrome, as it is a major risk factor for
cardiovascular diseases
and
type 2 diabetes
. Lifestyle changes and medications can sometimes prevent these negative outcomes.