Question

Holt-Oram syndrome is associated with

Answer 1

Holt-Oram syndrome is an autosomal dominant genetic disorder associated with skeletal abnormalities and congenital heart defects.

Step-by-step explanation:

Holt-Oram syndrome is an autosomal dominant genetic disorder characterized by skeletal abnormalities and congenital heart defects. It is primarily associated with mutations in the TBX5 gene, which is involved in the development of the heart and upper limbs. Individuals with Holt-Oram syndrome may have missing or underdeveloped thumbs, as well as other hand and arm abnormalities. They may also have heart defects, such as atrial septal defects or ventricular septal defects.