Final answer:
A wheal lesion is a soft, pale swelling surrounded by a red zone on the skin. An example of a wheal lesion is hives.
Step-by-step explanation:
A wheal lesion is a soft, pale swelling surrounded by a red zone on the skin. It is caused by the release of histamine and other mediators in response to allergens in type I hypersensitivity reactions. An example of a wheal lesion is hives, which are fluid-filled bumps on the skin that appear as raised and red patches.