Final answer:
Special handling procedures, such as keeping the samples warm and avoiding exposure to cold temperatures, are necessary for cold agglutinin samples to prevent agglutination.
Step-by-step explanation:
Special handling procedures are necessary for cold agglutinin samples to prevent the antibodies from binding and causing agglutination at low temperatures. These procedures include keeping the samples warm and avoiding exposure to cold temperatures during collection, transportation, and storage.
One method is to prewarm the collection tubes and maintain a warm environment throughout the handling process. This can be achieved by using incubators, warm water baths, or heated platforms.
Additionally, it is important to handle the samples gently to avoid mechanical stress, which can also trigger agglutination. Care should be taken when mixing or pipetting the samples to minimize the chances of clumping.