Question

Aminoglycosides given: _____ & _____.

DO NOT give PO, expect in these 3 cases:
1. _______ _______ (due to high _______ level).
2. Pre-op _______ surgery.
3. ___.______.

Answer 1

Aminoglycosides target bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to antibacterial effects but they are usually not given orally due to toxicity risks except for certain specific conditions related to the gastrointestinal tract.

Step-by-step explanation:

Aminoglycosides are a class of antibiotics that have a specific mechanism of action, targeting the bacterial ribosomal 30S subunit - a key component in protein synthesis. These drugs, which include gentamicin, streptomycin, and tobramycin, are known to cause cell death by creating faulty proteins that disrupt bacterial cell membranes. However, due to their potential nephrotoxicity, neurotoxicity, and ototoxicity, aminoglycosides are generally not administered orally (PO), except in specific situations like a high intestinal load in hepatic encephalopathy, preparation for gastrointestinal surgery, or in cases of bowel sterilization.