Final answer:
CMT disease, also known as Charcot-Marie-Tooth disease, is the most common inherited neuromuscular disorder. It is caused by genetic mutations that affect the nerves controlling muscles in the limbs. The typical presentation includes muscle weakness and wasting, especially in the lower limbs. The age of presentation can vary.
Step-by-step explanation:
CMT disease, also known as Charcot-Marie-Tooth disease, is the most common inherited neuromuscular disorder. It is caused by genetic mutations that affect the nerves controlling muscles in the limbs. The pathophysiology of CMT disease involves the degeneration of the myelin sheath, which leads to a slowdown in nerve signal transmission and muscle weakness.
The typical presentation of CMT disease includes muscle weakness and wasting, especially in the lower limbs. Patients may have difficulties with walking, balance, and fine motor skills. The age of presentation can vary, but symptoms often start appearing in childhood or adolescence.