Question

9 y/o F with Wilson's disease developed fulminant liver disease. 1st factor depleted (resulting in abnormality of what test)? 2 factors not depleted?

Answer 1

The first depleted factor in a 9-year-old with Wilson's disease and fulminant liver disease would be clotting factors, affecting coagulation tests, while levels of albumin and glucose are typically not depleted initially.

Step-by-step explanation:

In a 9-year-old female with Wilson's disease that has progressed to fulminant liver disease, the first factor to be depleted is likely to be clotting factors, which would result in abnormalities in blood coagulation tests such as prothrombin time (PT) and international normalized ratio (INR). The liver damage impairs the synthesis of these factors. In contrast, two factors that are typically not depleted in the early stages of acute liver failure are albumin and glucose, as these are either maintained through homeostatic mechanisms or have a longer half-life.