Final answer:
Desmopressin is the primary pharmaceutical treatment for children over 5 years old with frequent enuresis, followed by anticholinergic medications like Oxybutynin after a thorough evaluation. These should be used with healthcare provider supervision and possibly in conjunction with adjunctive treatments such as moisture alarms.
Step-by-step explanation:
The first line pharmacotherapy for enuresis in a child over 5 years old with more than two accidents per week typically involves the use of medication after behavioral interventions have been tried. The mainstay pharmacological treatment option is Desmopressin. This medication works by reducing urine production at night. Another option is the prescription of anticholinergic medication, such as Oxybutynin, which helps increase bladder capacity and reduce contractions. It is important to remember that these medications should only be used after thorough evaluation and under supervision by a healthcare provider. In addition, other adjunctive treatments like moisture alarms can be considered along with medication for better outcomes.