Final answer:
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis differ in severity and body surface area affected, with TEN being more severe. Large amounts of pro-inflammatory cytokines can lead to septic shock by triggering a systemic response that affects vascular function and organ perfusion, potentially causing organ failure and death.
Step-by-step explanation:
The difference between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) lies in their severity and extent of skin detachment. SJS and TEN are variants of the same condition, often seen as a spectrum, where SJS is at the milder end and TEN is the more severe form. Both conditions are characterized by a reaction that typically involves the skin and mucous membranes and are commonly triggered by medications.
SJS involves less than 10% of the body surface area, whereas TEN involves more than 30% of the body surface area. The mortality rate is higher in TEN. Both conditions require immediate medical attention and can cause serious complications, such as infections and organ failure.
Coming to the CHECK YOUR UNDERSTANDING question, large amounts of pro-inflammatory cytokines can lead to septic shock due to a systemic response that includes vasodilation, increased vascular permeability, and increased heart rate. This systemic reaction often results in significant hypotension, which can diminish perfusion of vital organs, leading to multi-organ dysfunction and potentially death.