Final answer:
Serum alkaline phosphatase is typically elevated in Paget's disease, reflecting increased bone turnover. Calcium and phosphorus levels may be normal or slightly raised, and urine hydroxyproline levels can also be elevated due to increased bone resorption. Bisphosphonates are commonly used to treat the disease and decrease osteoclast activity.
Step-by-step explanation:
In Paget's disease of bone, several lab tests are indicative of the disorder. Calcium (Ca) levels may vary; they can be normal or slightly increased. Serum phosphorus levels are generally normal or slightly elevated. A notable lab finding is an increase in serum alkaline phosphatase (ALP), which is typically elevated due to increased bone turnover. Urine hydroxyproline, a marker of bone resorption, may also be elevated, reflecting the high rate of bone turnover in Paget's disease.
This disease involves the disruption of normal bone remodeling, leading to the formation of new bone at a faster rate but in a disorganized manner. X-rays and bone scans using radioactive dye are helpful in diagnosing Paget's disease by showing bone deformities or areas of bone resorption. Treatment often includes drugs like bisphosphonates, which aim to decrease the activity of osteoclasts and help manage symptoms, reduce complications, and lower the risk of fractures.