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Patient with ascending polyneuropathy after a recent GI or respiratory infection. Dx? Pathology? LP findings?

User Pcv
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Final answer:

The patient likely has Guillain-Barré Syndrome, an autoimmune condition typically following an infection, which attacks the nervous system's myelin sheaths. Lumbar puncture findings usually show high protein with normal white cell count in the CSF, characteristic of this condition.

Step-by-step explanation:

Diagnosis and Pathology

The patient exhibits symptoms suggestive of Guillain-Barré Syndrome (GBS), a post-infectious polyneuropathy. GBS often follows a gastrointestinal or respiratory infection and is caused by an autoimmune reaction against the myelin sheath of peripheral nerves. This demyelination leads to ascending muscle weakness and varying degrees of paralysis.

Lumbar Puncture (LP) Findings

An LP is often performed to aid in the diagnosis of GBS. Typical findings include an elevated protein level in the cerebrospinal fluid (CSF) with a normal white cell count, a pattern referred to as 'albuminocytological dissociation'. These results help differentiate GBS from other conditions such as bacterial meningitis or viral encephalitis, where significant changes in white cell counts would be expected.

User Eugen Pechanec
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