Final answer:
Recurrent pulmonary and cutaneous infections with catalase positive organisms (such as s. aureus, serratia, burkholderia) may indicate a primary immunodeficiency disorder called chronic granulomatous disease (CGD). CGD is characterized by impaired phagocytic cells, specifically neutrophils and macrophages, which are unable to produce reactive oxygen species to kill invading organisms.
Step-by-step explanation:
Recurrent pulmonary and cutaneous infections with catalase positive organisms (such as s. aureus, serratia, burkholderia) may indicate a primary immunodeficiency disorder called chronic granulomatous disease (CGD). CGD is characterized by impaired phagocytic cells, specifically neutrophils and macrophages, which are unable to produce reactive oxygen species to kill invading organisms.
In CGD, the catalase-positive organisms mentioned are able to survive within the phagocytic cells due to their ability to produce catalase enzyme, which neutralizes reactive oxygen species such as hydrogen peroxide.
Diagnosis of CGD can be confirmed through genetic testing to detect mutations in genes that code for the components of the enzyme complex used for reactive oxygen species production.