Final answer:
Molecules of cholesterol and, or phospholipids. Both of these lipids are insoluble, therefore a protein carrier is needed for them to cross the cell membrane. This is a passive or facilitated transport process where molecules move from a high concentration to a low concentration. It is called diffusion.
Step-by-step explanation:
The question addresses the process of facilitated diffusion in passive transport, where cholesterol and phospholipids require protein carriers to move across cell membranes from regions of high to low concentration without energy expenditure.
Passive transport, specifically facilitated diffusion, relates to the movement of substances across biological membranes without the expenditure of energy. Insoluble lipids, like cholesterol and phospholipids, cannot easily cross the membrane on their own due to their hydrophobic nature. However, they can still move through a cell membrane with the help of proteins that facilitate their transport. This process allows molecules to diffuse from an area where they are in higher concentration to an area where they are in lower concentration.