Final answer:
Healthcare providers avoid aluminum salts in phosphate-binding agents for patients with renal failure and high serum phosphate to prevent osteodystrophy and potential aluminum toxicity.
Step-by-step explanation:
To avoid the development of osteodystrophy in a client with renal failure and associated high serum phosphate levels, healthcare providers generally try to avoid phosphate-binding agents that contain aluminum salts.
Aluminum-containing binders can lead to toxicity, particularly in patients with impaired renal function, and should be avoided if possible. Instead, other phosphate-binding agents such as calcium acetate, calcium carbonate, or sevelamer hydrochloride, which do not contain aluminum, are often used to control hyperphosphatemia.