A mutation in a gene that leads to a protein that is less sensitive to ubiquitin can have several potential effects on RNA and protein levels.
However, the specific outcomes would depend on the function of the gene and the role of ubiquitin in regulating the protein. In general, ubiquitin is a protein that plays a crucial role in the degradation of other proteins.
When a protein is tagged with ubiquitin, it is targeted for degradation by the proteasome. If the mutated protein is less sensitive to ubiquitin, it may be degraded more slowly, leading to an accumulation of the protein. Therefore, if the normal function of the gene is to produce a protein that is actively regulated by ubiquitin-mediated degradation.