Final answer:
The APC initiates anaphase by triggering the degradation of cohesin proteins, allowing sister chromatids to separate.
Step-by-step explanation:
The Anaphase Promoting Complex (APC) triggers the onset of anaphase by triggering the destruction of the cohesins that hold the sister chromatids together. This is essential for the separation of sister chromatids during anaphase. The cohesins are proteins that function as molecular glue, keeping the sister chromatids attached after DNA replication. As anaphase begins, the APC targets these cohesins for destruction, which allows the sister chromatids to separate and be pulled towards opposite poles of the cell by the spindle microtubules.