Question

Here are the frequencies of chromosomes: AB 0.2, aB 0.3, Ab, 0.3, ab 0.2. What is D, the disequilibrium coefficient?

-0

--0.05

-0.25

0.06

Answer 1

The disequilibrium coefficient (D) for the given frequencies of chromosomes (AB, aB, Ab, ab) is -0.05. It is found by using the formula D = f(AB) - (f(A)*f(B)), substituting the given frequencies into the formula.

Step-by-step explanation:

The disequilibrium coefficient (D) measures the difference between the observed frequency of a haplotype (a combination of alleles at different loci) and the expected frequency of that haplotype if the alleles were combining randomly according to the Hardy-Weinberg principle. The coefficient can be calculated using the formula D = f(AB) - (f(A)*f(B)), where f(AB) is the frequency of the AB haplotype, and f(A) and f(B) are the frequencies of the individual A and B alleles, respectively.

To calculate D for the given chromosomes, let's assign the allele frequencies as follows: f(A) = f(AB) + f(Ab), and f(B) = f(AB) + f(aB). Plugging these values into the formula for D:

So the disequilibrium coefficient D is -0.05.

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