Question

Deficiency in RAG-1 and/or RAG-2 can affect the proper development of which of the following cell types, resulting in decreased numbers of circulating cells of those types?

Answer 1

Deficiency in RAG-1 and/or RAG-2 can affect the proper development of B and T cells, resulting in decreased numbers of circulating cells of those types. Individuals with this deficiency may experience immunodeficiency and increased susceptibility to infections.

Step-by-step explanation:

Deficiency in RAG-1 and/or RAG-2 can impact the proper development of B and T cells, resulting in decreased numbers of circulating cells of those types.

RAG-1 and RAG-2 are important enzymes involved in the process of V(D)J recombination, which is necessary for the generation of diverse antigen receptors on B and T cells. Without functional RAG-1 and RAG-2, the development of B and T cells is impaired, leading to decreased numbers of these cells in the bloodstream.

As a result, individuals with a deficiency in RAG-1 and/or RAG-2 may experience immunodeficiency, making them more susceptible to infections.