Final answer:
The predilection site of Hepatozoon spp. is the hepatocytes, the major cells of the liver where these parasites reside and replicate.
Step-by-step explanation:
The predilection site of Hepatozoon spp. is the hepatocytes, which are the major functional cells of the liver. These parasites infect the hepatocytes and utilize them to complete part of their life cycle.
In the context of parasitic infections, the term 'predilection site' refers to the specific location in the host's body where a parasite prefers to live or is most commonly found. In this instance, Hepatozoon spp. show a preference for the liver's functional cells, the hepatocytes, where they can replicate and survive.