Final answer:
According to Koch's postulates, one of the requirements to prove that any given infectious agent causes a certain disease is that the pathogen must be cultured and isolated from every case of the disease. However, this is not always possible with all pathogens, such as viruses and prions.
Step-by-step explanation:
Koch's postulates are a set of criteria used to determine whether a particular microorganism is the cause of a specific disease. One of the requirements is that the pathogen must be cultured and isolated from every case of the disease. However, this is not always possible with all pathogens, such as viruses and prions, which fail to meet the second postulate. Therefore, the correct answer is option C) the disease is caused by a combination of infectious pathogens and environmental factors.